Zepbound, which is already sold by Eli Lilly as the diabetes treatment Mounjaro, was shown to reduce patients’ weight by as much as one-fifth in drug trials.
  • @xohshoo
    7•1 year ago

    So now with 5 similar meds on the market, we should see some price drops, right?

    Oh who am I kidding, prices will go up

    • @reddig33
      1•1 year ago

      It will be fascinating to see what happens by the time there are generic versions of these meds available.

      • @SludgehammerEnglish
        2•1 year ago

        I’m guessing they’ll be off the market before a generic version can be made. I might just be prejudiced by living through the Fen-phen craze, but I fully expect they’ll find most of these weight loss drugs cause some sort of health issues.

        • @iamtherealwalrusEnglish
          2•1 year ago

          I fully expect they’ll find most of these weight loss drugs cause some sort of health issues.

          But will these health issues be worse than obesity itself? Almost all medicines have side effects, the job is figuring out which is worse: the condition they treat or the side effects from the medicine.

  • @Delphia
    1•1 year ago

    Ok can any doctors please explain the why of this to me.

    I hit the gym 4 to 6 days a week, diet is pretty much spot on but Ive really hit a wall on progress, but if I want to any pharmaceutical assistance from a reputable source and managed by a physician I get told “No! Thats performance enhancing!” Fucking DUH, thats why I want it. But no, I have to either buy rando shit offline or get pills out of some guys gym bag from next to his dirty socks.

    But if you want to eat yourself to the point of needing medical intervention so you dont die early you have a range of different medications and elective surgeries to choose from. Thats without even getting started on cosmetic surgery.

    Im not like raging angry about this or anything it just seems kind of fucked, most supplements have extremely mild benefits at best, are an absolute waste of money in most cases, and can be harmful at worst. But we have a range of options that are full well known to work, but are illegal because side effects.

  • AutoTL;DRBEnglish
    1•1 year ago

    This is the best summary I could come up with:

    But until now, Wegovy — also semaglutide but with a higher maximum dose than Ozempic — was the only approved drug that could safely elicit substantial weight loss in people with obesity alone.

    Susan Yanovski, co-director of the office of obesity research at the National Institute of Diabetes and Digestive and Kidney Diseases, said, “Just a few years ago it would be difficult to imagine two medications like semaglutide and tirzepatide that lead to weight loss that previously was only seen when people had bariatric surgery,” referring to a surgical treatment that is a proven effective treatment for obesity.

    In a packed room at a meeting of the American Diabetes Association last year, the study’s principal investigator, Dr. Ania Jastreboff of Yale, revealed the results.

    More than half the patients receiving the highest dose lost at least 20 percent of their body weight.No drug has ever before shown such a profound weight loss.

    “Obesity wasn’t a main focus for us,” Dr. Daniel Skovronsky, the chief scientific and medical officer at Eli Lilly, said, adding that “it was not seen as a commercial opportunity.”

    The hope is that Zepbound can reduce the chances that people with obesity will develop the potentially deadly complications that accompany the condition.

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