For me “How long could I get away with driving like an ABSOLUTE ASSHOLE all the time before I lost my licence or had an accident.” Speed limits, red lights, stop signs… forget them all. Every day I have to drive sensibly and obey the law because without my licence I dont have a job, and every day I see at least one person driving like an absolute moron and I wonder…
Most people are very opposed to eugenics and genetic modification of humans. There is infinite opportunity for unexpected disasters along the way to perfection, and it’s extremely apathetic to be okay with subjecting a sentient creature to the possible ramifications of unexpected outcomes.