Your first example needs metabolized into an active ingredient. The second is an active ingredient.
There’s a bunch of different liver enzymes at play, and an absolute shit ton of normal variation between people.
Too much of those enzymes, and you burn through a 12 hr oxy in 6 hours, which makes people likely to abuse their own medication and can lead to life long addicts.
Too little and you get zero effect from “normal” opioids, but fentanyl, morphine, and other direct action opioids stick around for a lot longer and you have no tolerance.
Well, yeah…
Your first example needs metabolized into an active ingredient. The second is an active ingredient.
There’s a bunch of different liver enzymes at play, and an absolute shit ton of normal variation between people.
Too much of those enzymes, and you burn through a 12 hr oxy in 6 hours, which makes people likely to abuse their own medication and can lead to life long addicts.
Too little and you get zero effect from “normal” opioids, but fentanyl, morphine, and other direct action opioids stick around for a lot longer and you have no tolerance.
That’s what I’m saying:
Yes I was just sharing a side-thought while agreeing and sharing a story.