Summary

Bryan Johnson, a 46-year-old tech multimillionaire focused on anti-aging, stopped using rapamycin—a supplement he took for five years—after research suggested it might accelerate aging.

Johnson cited side effects like skin infections and glucose issues, as well as findings from a recent study showing rapamycin could worsen epigenetic aging.

Known for extreme anti-aging experiments, Johnson also created the health startup Blueprint, which markets pricey supplements.

His controversial methods, including teenage blood transfusions and genital shock treatments, have raised skepticism about their effectiveness and safety.

  • @iAvicenna
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    2 hours ago

    Is this the trickle down economics everyone is talking about? shall we again start selling uranium, platinum etc beverages to the rich?

    He has a team for this?

    “Despite the immense potential from pre-clinical trials, my team and I came to the conclusion…"

    Forget trickle down economics, this is insane just bring the guillotines.

  • @Aqarius
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    54 hours ago

    I see the proud tradition of drinking mercury concoctions is alive and well. I mean, not well, but…

  • @BigBenis
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    136 hours ago

    This guy looks like he’s 60 cosplaying as a 20 year old

  • @aesthelete
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    24 hours ago

    This is one of the biggest wastes of time I could imagine.

  • @Mediocre_Bard
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    67 hours ago

    It would be hilarious if the societal collapse caused by wealth inequality resulted in him getting murdered. I would laugh and laugh.

    • @Woht24
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      -14 hours ago

      To think that a societal collapse would stop a billionaire from hiring armed guards is absurd. By the time that guy is murdered, you’ll be so long dead.

  • @yrnttm
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    1610 hours ago

    This dude is just going to spend a bunch of money on shit that will eventually kill him. What a waste.

    • @aesthelete
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      34 hours ago

      What an efficient allocation of capital!

      • @aesthelete
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        4 hours ago

        Nah some of the shit we buy sustains us, and some of the killer shit we buy at least provides joy. This guy is just a miserable, wasteful asshole.

      • @ours
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        13 hours ago

        You have to see this guy’s routine. His life is built around attempting to extend his longevity. He lives like a luxurious lab rat being pocked, prodded, measured and eats/drinks/sleeps/exercises on a ultra-strick program.

        It seems miserable.

  • Lettuce eat lettuce
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    37 hours ago

    It would be hilarious if the accelerated aging from the supplement undid all the progress he made from all the other stuff lol.

  • @[email protected]
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    3414 hours ago

    Watched the documentary with a friend; we were trying to guess his age. We agreed on “decent looking for 55”. He’s 47 lol.

    • @ameancow
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      13 hours ago

      People who are obsessed with some physical quality about themselves always make whatever the issue is, like 1000% worse than if they just left it alone and lived normally.

    • @Buddahriffic
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      1213 hours ago

      His face looks old enough to make his hair look unnatural.

  • @jaybone
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    1713 hours ago

    Had to check this wasn’t nottheonion

  • @Alphamars
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    39 hours ago

    You can’t cheat life. We must all age…

    • @[email protected]
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      34 hours ago

      He seems to actually believe there is a way to live forever. And he’s spending millions per year to get there. He said he wants to show the world how to stop ageing. When asked how everybody should be able to spend as much resources as he does, he said society has to figure that out. Besides the fact that cost-intense trestments will only benefit the wealthy there wasn’t one word about overall resource management, when people will die much later, but babies are born continuously. And the sentence about society has to figure it out really made me angry. Society already figured out billionairs are an issue and often enough the cause for many poor people suffering. But this doesn’t change anything, cause the rich make the rules.

  • Jo Miran
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    19320 hours ago

    It’s an unpopular opinion, but I actually appreciate this guy and what he is doing. He has opted to open his entire research and data to anyone that wants to look at it. So, even though he is definitely a weirdo, the data he is providing might be of some use.

    I don’t want to look like a vampire, but if his research leads to the discovery of some protein that allows my heart to beat at full strength for a little longer, or slows down the onset of dementia, etc., then I’m all for him wasting his money trying to look like a Twilight cast member.

    • @trashgirlfriend
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      4 hours ago

      It’s one guy who is going through like a million treatments.

      It’s cool that the data is available but what helpful information can be gained from it other than “what happens if you do jackass but healthy?”

    • @[email protected]
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      11819 hours ago

      I like that he’s willing to really fuck up his own body to see what happens. I don’t like that he’s peddling supplements.

      • Jo Miran
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        4819 hours ago

        Notice I used the word “appreciate” instead of “like”.

    • IninewCrow
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      5119 hours ago

      This isn’t real research … it’s just a millionaire spending money on trying to live longer for themselves while selling and marketing products on the side.

      If it were real research, it would involve a group of recognized researchers and scientists testing products and activities on a small group of volunteers who are fully aware of what they are participating in. And the research has to last for several years using multiple controls.

      Watching one guy testing and trying out a few things whenever he feels like it and done at his own whim and under only his opinion and likes and dislikes is not research.

      The biggest contribution he has to longevity is in promoting and advertising the fact that one of the ways to extend your lifespan is to become a millionaire.

      • @Zombiepirate
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        1513 hours ago

        You’re telling me that shocking one’s nards on a hunch and writing it down isn’t real research?

        I’m starting to think I know nothing about science. What have I been doing?

        • IninewCrow
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          512 hours ago

          I’d love to see your research on shocking your nards … especially to be able to see the video evidence of what happens and what the results are.

      • @[email protected]
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        12 hours ago

        If it were real research, it would involve a group of recognized researchers and scientists testing products and activities on a small group of volunteers who are fully aware of what they are participating in. And the research has to last for several years using multiple controls.

        For most of the time since the start of the Scientific Revolution, the way this guy does research was the standard way that research was done. Controlled clinical trials certainly have an important role in the development of new medicines, but they’re slow and expensive. They aren’t good tools for quickly trying out a lot of very speculative ideas. I expect that if a powerful anti-aging technique is discovered, it will be used for self-experimentation years before a clinical trial.

        A couple of caveats: first, I think that a powerful anti-aging technique is probably not possible with today’s technology or the technology of the near future. Second, I think the self-experimentation is more likely to be done by a scientist in an academic lab studying senescence than by someone doing research outside of academia.

    • @livjq
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      5719 hours ago

      But he’s involving so many variables, is his data even useful? I don’t understand how you could extrapolate anything from a guy who takes so many supplements that may cause conflicting outcomes.

      • @[email protected]
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        4119 hours ago

        Someone who has a background in science would know that testing on a single person is not very useful for what other posters are wishing for (new proteins, new anti aging treatments).

        This billionaire has age dysmorphia and is using his wealth to experiment around. It’s unfortunate really.

        • @[email protected]
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          210 hours ago

          It’s unethical to experiment on anyone other than yourself, but there’s a reason we can cure so many things in mice, and it isn’t just that they’re a bit simpler. It’s also because they go through a lot of mice.

        • @Sludgehammer
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          714 hours ago

          It’s unfortunate really.

          I don’t know about “unfortunate”. His “move fast and break things” approach to anti-aging treatments have a good chance of killing him, and having one less dipshit billionaire who thinks he’s brilliant because he’s rich would undoubtedly benefit society as a whole.

      • @Serinus
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        718 hours ago

        Yes, because anything that looks promising can be pulled out as a hypothesis to be tested properly.

    • @[email protected]
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      1319 hours ago

      A sample size of one is pretty much useless. The only good thing to come out of his work is the publicity and public interest in anti aging imo.

      • @quixotic120
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        716 hours ago

        Single case design is a field of a research that can provide a great deal of value on efficacy for worth of larger trials but the way he’s approaching it, as others have said, is functionally useless. The data is likely pointless if you’ve thrown 100 confounding variables at the wall to see what sticks